XPO5

Across TCGA pan-cancer cohorts, XPO5 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated XPO5 data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher XPO5 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated XPO5 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, LIHC, and MESO are the cancer types where XPO5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.938	0.300	.005	28	view →
LIHC	OS	Median	All	0.186	0.782	<.001	27	view →
MESO	OS	Median	All	0.130	0.557	.019	18	view →
SKCM	DFS	Median	All	0.248	0.763	<.001	18	view →
COAD	OS	Median	III,IV	0.159	0.692	.021	9	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

XPO5–UCEC (DFS)

Open the UCEC breakdown →