XPO5

Across TCGA patient cohorts, XPO5 protein abundance is significantly associated with the RNA expression of many other genes, with 22,254 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible XPO5-associated genes across cancer lineages are MCM3, RPP40, and PRIM2. Each is linked with XPO5 in more than 9 cancer types. Because this analysis shows association rather than direction, both XPO5-to-partner and partner-to-XPO5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XPO5 versus MCM3 in LSCC, with a Pearson correlation of 0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO5→partner) and Y-score (partner→XPO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MCM3 →	+0.947	+0.666	<.001	<.001	3	10
LSCC	RPP40 →	+0.941	+0.743	<.001	<.001	3	10
LSCC	PRIM2 →	+0.792	+0.687	<.001	<.001	3	10
LSCC	POLR1C →	+0.849	+0.765	<.001	<.001	3	10
GBM	KIFC1 →	+1.293	+0.506	<.001	<.001	3	10
LSCC	SRPK1 →	+0.764	+0.697	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 22,254 associations by consensus.

XPO5 vs MCM3 — LSCC

Explore this scatter interactively →