XPO5

Across TCGA patient cohorts, XPO5 mutation is significantly associated with the RNA expression of many other genes, with 2,579 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPO5-associated genes across cancer lineages are RNA5SP145, MIR373, and RNU6-752P. Each is linked with XPO5 in more than 3 cancer types. Because this analysis shows association rather than direction, both XPO5-to-partner and partner-to-XPO5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP145 grouped by XPO5-low versus XPO5-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO5→partner) and Y-score (partner→XPO5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	RNA5SP145 →	+0.396	+5.645	<.001	<.001	3	4
ESCA	MIR373 →	+0.639	+4.476	.002	.005	3	3
KIRP	RNU6-752P →	+0.402	+5.928	.002	.002	3	3
UCEC	GLRX5 →	+0.367	+1.970	.001	<.001	3	3
UCEC	LRRC10B →	-1.127	-1.938	.001	.001	3	3
UCEC	RNU6-1069P →	+0.811	+1.516	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,579 associations by consensus.

RNA5SP145 by XPO5 expression — LIHC

Explore this box plot interactively →