XPO1

Across TCGA pan-cancer cohorts, XPO1 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated XPO1 data layer compared with 28 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher XPO1 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated XPO1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, CESC, and STAD are the cancer types where XPO1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.975	0.610	.001	36	view →
CESC	OS	Median	II,III,IV	0.068	0.830	<.001	24	view →
STAD	OS	Median	III,IV	0.184	0.641	.011	6	view →
COAD	OS	Median	III,IV	0.168	0.691	.041	6	view →
ESCA	DFS	Median	All	0.075	0.504	<.001	6	view →
SARC	DFS	Median	All	0.130	0.632	.045	3	view →
SKCM	DFS	Median	All	1.000	0.717	.020	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

XPO1–UCEC (DFS)

Open the UCEC breakdown →