XPO1

Across TCGA pan-cancer cohorts, XPO1 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated XPO1 data layer compared with 28 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher XPO1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated XPO1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and OV show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where XPO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.618	0.889	<.001	62	view →
HNSC	OS	Tertile	All	0.167	1.000	.010	57	view →
CCRCC	DFS	Median	All	0.701	0.906	.003	30	view →
LSCC	DFS	Quartile	II,III,IV	0.851	0.378	.010	9	view →
OV	DFS	Median	All	0.917	0.534	.020	8	view →
COAD	DFS	Median	IV	0.260	0.894	.014	6	view →
LUAD	DFS	Median	III,IV	0.879	0.631	.035	3	view →
UCEC	DFS	Tertile	All	0.931	1.000	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

XPO1–PDAC (DFS)

Open the PDAC breakdown →