XPO1

Across TCGA patient cohorts, XPO1 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPO1-associated genes across cancer lineages are GAPDH, JNK_pT183_Y185, and C-Raf. Each is linked with XPO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both XPO1-to-partner and partner-to-XPO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by XPO1-low versus XPO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPO1→partner) and Y-score (partner→XPO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.410	+2.321	.010	.005	3	3
UCEC	JNK_pT183_Y185 →	-0.160	-1.999	.001	.002	3	3
BRCA	C-Raf →	+0.200	+2.814	.028	.037	3	2
UCEC	eIF4E →	+0.142	+2.169	.023	.003	3	2
UCEC	FOXO3a_pS318_S321 →	-0.073	-1.142	.048	.048	3	2
UCEC	GATA6 →	-0.121	-1.792	.010	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

GAPDH by XPO1 expression — UCEC

Explore this box plot interactively →