XPNPEP2

Across TCGA patient cohorts, XPNPEP2 mutation is significantly associated with the RNA expression of many other genes, with 2,660 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPNPEP2-associated genes across cancer lineages are ZNF367, ENTR1, and PLK1. Each is linked with XPNPEP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both XPNPEP2-to-partner and partner-to-XPNPEP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF367 grouped by XPNPEP2-low versus XPNPEP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPNPEP2→partner) and Y-score (partner→XPNPEP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNF367 →	+0.595	+1.758	<.001	.003	3	3
UCEC	ENTR1 →	+0.368	+1.627	<.001	<.001	3	3
UCEC	PLK1 →	+0.467	+1.668	.009	.003	3	3
UCEC	PBK →	+0.561	+1.233	.006	.008	3	3
UCEC	CKAP2L →	+0.442	+1.483	.007	.007	3	3
UCEC	RRM2 →	+0.651	+1.584	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,660 associations by consensus.

ZNF367 by XPNPEP2 expression — UCEC

Explore this box plot interactively →