XPNPEP2

Across TCGA patient cohorts, XPNPEP2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XPNPEP2-associated genes across cancer lineages are ATM, 4E-BP1, and Cyclin-B1. Each is linked with XPNPEP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both XPNPEP2-to-partner and partner-to-XPNPEP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by XPNPEP2-low versus XPNPEP2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPNPEP2→partner) and Y-score (partner→XPNPEP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ATM →	-0.604	-3.000	.010	.034	3	4
UCEC	4E-BP1 →	+0.226	+2.584	.006	.010	3	3
UCEC	Cyclin-B1 →	+0.572	+1.700	<.001	.001	3	3
LUAD	4E-BP1_pT37_T46 →	-0.392	-3.169	.046	.019	3	2
UCEC	MSH6 →	-0.303	-1.415	.002	.040	3	2
UCEC	Caspase-7-cleavedD198 →	+0.692	+1.827	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ATM by XPNPEP2 expression — LUAD

Explore this box plot interactively →