XPNPEP1

Across TCGA pan-cancer cohorts, XPNPEP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated XPNPEP1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher XPNPEP1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated XPNPEP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and LUAD are the cancer types where XPNPEP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.445	.002	38	view →
PDAC	OS	Median	All	0.635	0.447	.001	31	view →
LUAD	OS	Tertile	II,III,IV	0.433	0.841	.006	16	view →
COAD	DFS	Median	III,IV	0.897	1.000	.044	6	view →
LSCC	DFS	Quartile	II,III,IV	0.887	0.198	.024	4	view →
CCRCC	DFS	Tertile	III,IV	0.887	0.198	.024	3	view →
GBM	DFS	Median	All	0.402	0.235	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

XPNPEP1–UCEC (DFS)

Open the UCEC breakdown →