XPNPEP1

Across TCGA cell cohorts, XPNPEP1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible XPNPEP1-associated genes across cancer lineages are MAGEB5, OBP2A, and C20orf85. Each is linked with XPNPEP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both XPNPEP1-to-partner and partner-to-XPNPEP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by XPNPEP1-low versus XPNPEP1-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPNPEP1→partner) and Y-score (partner→XPNPEP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Leukemia	OBP2A →	+0.044	+4.984	<.001	.002	3	1
BLOOD_Leukemia	C20orf85 →	+0.029	+4.384	<.001	.006	3	1
BLOOD_Leukemia	IL22 →	+0.030	+4.984	<.001	.002	3	1
BLOOD_Leukemia	HCN4 →	+0.056	+3.855	<.001	.007	3	1
BLOOD_Leukemia	ASZ1 →	+0.112	+4.567	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MAGEB5 by XPNPEP1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →