XPC

Across TCGA pan-cancer cohorts, XPC mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated XPC data layer compared with 23 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher XPC mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated XPC expression acts as an unfavorable survival marker, although some lineages such as CCRCC and COAD show a favorable association.

UCEC, CCRCC, and COAD are the cancer types where XPC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.469	0.944	.003	44	view →
CCRCC	DFS	Median	All	0.929	0.551	.007	11	view →
COAD	DFS	Median	III,IV	1.000	0.846	.049	6	view →
LUAD	OS	Quartile	III,IV	0.779	0.420	.019	4	view →
PDAC	DFS	Median	All	0.881	0.716	.037	2	view →
HNSC	DFS	Quartile	III,IV	1.000	0.368	.049	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

XPC–UCEC (DFS)

Open the UCEC breakdown →