XPC

Across TCGA patient cohorts, XPC protein abundance is significantly associated with the RNA expression of many other genes, with 11,248 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible XPC-associated genes across cancer lineages are ERO1A, CEP55, and SLC25A26. Each is linked with XPC in more than 6 cancer types. Because this analysis shows association rather than direction, both XPC-to-partner and partner-to-XPC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XPC versus ERO1A in LSCC, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPC→partner) and Y-score (partner→XPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ERO1A →	-0.813	-0.236	.002	.004	3	7
UCEC	CEP55 →	-0.947	-0.239	<.001	<.001	3	6
OV	SLC25A26 →	+0.510	+0.319	.003	.008	3	6
UCEC	BUB1 →	-1.188	-0.276	<.001	<.001	3	6
HNSC	IL1A →	-1.723	-0.235	<.001	<.001	3	6
BRCA	TTK →	-0.950	-0.345	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,248 associations by consensus.

XPC vs ERO1A — LSCC

Explore this scatter interactively →