XPC

Across TCGA cell cohorts, XPC RNA expression is significantly associated with the go_rna of many other GO terms, with 3,632 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible XPC-associated GO terms across cancer lineages are Retrograde transport, endosome to Golgi, Cytosolic transport, and Protein polyglycylation. Each is linked with XPC in more than 13 cancer types. Because this analysis shows association rather than direction, both XPC-to-partner and partner-to-XPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Retrograde transport, endosome to Golgi grouped by XPC-low versus XPC-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XPC→partner) and Y-score (partner→XPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Retrograde transport, endosome to Golgi →	+0.095	+1.080	<.001	<.001	3	14
STOMACH	Cytosolic transport →	+0.063	+0.838	.001	.008	2	14
STOMACH	Protein polyglycylation →	+1.290	+1.052	<.001	<.001	3	13
SKIN	Negative regulation of transcription by RNA polymerase III →	+0.183	+0.947	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of telomere maintenance →	+0.075	+1.094	.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.149	-1.503	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,632 associations by consensus.

Retrograde transport, endosome to Golgi by XPC expression — OESOPHAGUS

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