XPC

Across TCGA cell cohorts, XPC mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XPC-associated genes across cancer lineages are GSTA5, KANK4, and CLDN8. Each is linked with XPC in more than 1 cancer types. Because this analysis shows association rather than direction, both XPC-to-partner and partner-to-XPC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSTA5 grouped by XPC-low versus XPC-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XPC→partner) and Y-score (partner→XPC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GSTA5 →	+0.035	+4.930	<.001	.008	3	1
BLOOD_Leukemia	KANK4 →	+1.360	+3.504	<.001	.004	3	1
BLOOD_Leukemia	CLDN8 →	+0.009	+2.971	<.001	.003	3	1
BLOOD_Leukemia	MBD3L5 →	+0.013	+3.984	<.001	.006	3	1
BLOOD_Leukemia	CNTNAP3C →	+0.081	+3.051	<.001	.006	3	1
SKIN	CCL25 →	+0.058	+4.095	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

GSTA5 by XPC expression — SOFT_TISSUE

Explore this box plot interactively →