Across TCGA pan-cancer cohorts, XPC-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated XPC-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher XPC-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated XPC-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, BLCA, and UCS are the cancer types where XPC-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.780	0.629	.001	101	view →
BLCA	OS	Quartile	All	0.618	0.315	<.001	80	view →
UCS	DFS	Median	IV	0.952	0.367	.001	72	view →
KIRC	DFS	Tertile	II,III,IV	0.409	0.645	.002	54	view →
LGG	DFS	Median	All	0.297	0.482	<.001	54	view →
SKCM	OS	Quartile	III,IV	0.596	0.283	.001	45	view →
READ	OS	Tertile	All	0.889	0.292	<.001	38	view →
MESO	DFS	Median	III,IV	0.266	0.459	.003	33	view →
LUSC	DFS	Tertile	III,IV	0.539	1.000	.008	22	view →
BRCA	OS	Tertile	III,IV	0.968	0.843	.003	18	view →
PRAD	DFS	Median	All	0.828	0.932	<.001	18	view →
ACC	DFS	Tertile	IV	0.190	0.802	.002	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

Exploration

Same gene, other analysis: XPC-AS1 tumor-vs-normal RNA expression · all XPC-AS1 data types