XKRX

Across TCGA patient cohorts, XKRX protein abundance is significantly associated with the RNA expression of many other genes, with 216 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible XKRX-associated genes across cancer lineages are HMGXB4, CD9, and ELOB. Each is linked with XKRX in more than 1 cancer types. Because this analysis shows association rather than direction, both XKRX-to-partner and partner-to-XKRX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XKRX versus HMGXB4 in LUAD, with a Pearson correlation of 0.73.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKRX→partner) and Y-score (partner→XKRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HMGXB4 →	+0.637	+1.111	.004	.004	3	1
LUAD	CD9 →	-1.240	-1.112	.003	.004	3	1
LUAD	ELOB →	-0.798	-1.112	.001	.004	3	1
LUAD	HMOX2 →	-0.892	-1.111	<.001	.004	3	1
LUAD	CEMIP →	+2.409	+1.112	.001	.004	3	1
LUAD	R3HCC1 →	+0.666	+1.112	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 216 associations by consensus.

XKRX vs HMGXB4 — LUAD

Explore this scatter interactively →