XKRX

Across TCGA patient cohorts, XKRX mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XKRX-associated genes across cancer lineages are eIF4E, FASN, and PKC-delta_pS664. Each is linked with XKRX in more than 1 cancer types. Because this analysis shows association rather than direction, both XKRX-to-partner and partner-to-XKRX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by XKRX-low versus XKRX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKRX→partner) and Y-score (partner→XKRX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.172	+1.765	.029	.014	3	2
UCEC	FASN →	+0.339	+1.415	.021	.046	3	2
UCEC	PKC-delta_pS664 →	-0.110	-2.584	.014	.010	3	2
UCEC	4E-BP1 →	+0.434	+3.837	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.093	-2.432	.014	.018	3	1
UCEC	FoxM1 →	+0.306	+2.662	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eIF4E by XKRX expression — UCEC

Explore this box plot interactively →