Across TCGA patient cohorts, XKR9 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XKR9-associated genes across cancer lineages are Akt_pT308, Annexin-1, and 14-3-3_beta. Each is linked with XKR9 in more than 1 cancer types. Because this analysis shows association rather than direction, both XKR9-to-partner and partner-to-XKR9 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR9→partner) and Y-score (partner→XKR9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Akt_pT308 →	+0.517	+3.000	.047	.001	3	2
UCEC	Annexin-1 →	+0.493	+3.189	.023	.010	3	2
UCEC	14-3-3_beta →	-0.113	-2.308	.006	.006	3	1
UCEC	EGFR_pY1068 →	-0.225	-1.807	.030	.027	3	1
UCEC	Heregulin →	-0.126	-3.459	.013	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.167	-2.321	.016	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

XKR9 survival (RNA) · tumor vs normal (RNA) · all XKR9 data types