XKR8

Across TCGA patient cohorts, XKR8 protein abundance is significantly associated with the RNA expression of many other genes, with 436 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible XKR8-associated genes across cancer lineages are GCAT, TOMM22, and RBX1. Each is linked with XKR8 in more than 1 cancer types. Because this analysis shows association rather than direction, both XKR8-to-partner and partner-to-XKR8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XKR8 versus GCAT in LUAD, with a Pearson correlation of -0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR8→partner) and Y-score (partner→XKR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GCAT →	-1.155	-0.647	.005	.001	3	1
LUAD	TOMM22 →	-0.435	-0.534	.007	.005	3	1
LUAD	RBX1 →	-0.344	-0.641	.004	.001	3	1
LUAD	SOS2 →	+0.679	+0.574	<.001	<.001	3	1
LUAD	LHB →	+0.852	+0.572	<.001	<.001	3	1
LUAD	TNNT1 →	+2.648	+0.469	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 436 associations by consensus.

XKR8 vs GCAT — LUAD

Explore this scatter interactively →