XKR8

Across TCGA cell cohorts, XKR8 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,140 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible XKR8-associated GO terms across cancer lineages are Neutrophil clearance, Neutrophil homeostasis, and Macroautophagy. Each is linked with XKR8 in more than 14 cancer types. Because this analysis shows association rather than direction, both XKR8-to-partner and partner-to-XKR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Neutrophil clearance grouped by XKR8-low versus XKR8-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR8→partner) and Y-score (partner→XKR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Neutrophil clearance →	-0.182	-0.950	<.001	<.001	3	15
SOFT_TISSUE	Neutrophil homeostasis →	-0.198	-1.836	<.001	<.001	3	12
LUNG_NSCLC_LUAD	Macroautophagy →	+0.046	+0.584	<.001	.004	3	10
BLOOD_Lymphoma	Positive regulation of viral process →	+0.085	+0.981	<.001	<.001	3	9
BLOOD_Lymphoma	Negative regulation of myoblast fusion →	+0.110	+1.093	<.001	<.001	3	9
CNS	Vacuole organization →	+0.031	+0.843	.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,140 associations by consensus.

Neutrophil clearance by XKR8 expression — BONE

Explore this box plot interactively →