XKR7

Across TCGA patient cohorts, XKR7 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XKR7-associated genes across cancer lineages are PKC-b-II_pS660, PDCD4, and TFRC. Each is linked with XKR7 in more than 2 cancer types. Because this analysis shows association rather than direction, both XKR7-to-partner and partner-to-XKR7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by XKR7-low versus XKR7-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR7→partner) and Y-score (partner→XKR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PKC-b-II_pS660 →	-0.418	-3.169	.001	.018	3	3
UCEC	PDCD4 →	-0.819	-3.690	<.001	.001	3	2
UCEC	TFRC →	+0.665	+2.807	.004	.003	3	2
SKCM	PARP_cleaved →	+0.161	+2.321	.021	.033	3	2
COAD	Annexin-1 →	+0.615	+2.815	.003	.036	3	2
BLCA	GATA3 →	+0.602	+3.000	.041	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PKC-b-II_pS660 by XKR7 expression — SKCM

Explore this box plot interactively →