XKR7

Across TCGA cell cohorts, XKR7 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,287 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible XKR7-associated GO terms across cancer lineages are Positive regulation of DNA recombination, Negative regulation of peptidase activity, and Regulation of DNA recombination. Each is linked with XKR7 in more than 6 cancer types. Because this analysis shows association rather than direction, both XKR7-to-partner and partner-to-XKR7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA recombination grouped by XKR7-low versus XKR7-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR7→partner) and Y-score (partner→XKR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of DNA recombination →	+0.075	+0.037	<.001	<.001	3	7
BLOOD_Lymphoma	Negative regulation of peptidase activity →	-1.000	-0.035	<.001	<.001	3	5
BLOOD_Lymphoma	Regulation of DNA recombination →	+0.070	+0.032	<.001	.002	3	5
BLOOD_Lymphoma	Positive regulation of double-strand break repair via homologous recombination →	+0.091	+0.047	<.001	<.001	3	5
LUNG_SCLC	Mitotic cell cycle phase transition →	+0.079	+2.276	<.001	<.001	3	5
BLOOD_Lymphoma	Transcription initiation at RNA polymerase II promoter →	+0.043	+0.038	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,287 associations by consensus.

Positive regulation of DNA recombination by XKR7 expression — BLOOD_Lymphoma

Explore this box plot interactively →