XKR6

Across TCGA patient cohorts, XKR6 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XKR6-associated genes across cancer lineages are TFRC, ASNS, and ATM. Each is linked with XKR6 in more than 2 cancer types. Because this analysis shows association rather than direction, both XKR6-to-partner and partner-to-XKR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by XKR6-low versus XKR6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR6→partner) and Y-score (partner→XKR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	TFRC →	+0.482	+3.000	.020	.034	3	3
UCEC	ASNS →	+0.281	+1.584	.007	.032	3	3
UCEC	ATM →	-0.591	-2.459	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.562	+2.146	<.001	<.001	3	3
UCEC	eIF4E →	+0.166	+1.906	.006	<.001	3	2
UCEC	ACC1 →	+0.239	+1.295	.024	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

TFRC by XKR6 expression — SKCM

Explore this box plot interactively →