XKR6

Across TCGA cell cohorts, XKR6 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,080 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible XKR6-associated GO terms across cancer lineages are Engulfment of apoptotic cell, Phosphatidylserine exposure on apoptotic cell surface, and Peptidyl-amino acid modification. Each is linked with XKR6 in more than 8 cancer types. Because this analysis shows association rather than direction, both XKR6-to-partner and partner-to-XKR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Engulfment of apoptotic cell grouped by XKR6-low versus XKR6-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR6→partner) and Y-score (partner→XKR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Engulfment of apoptotic cell →	-0.400	-1.455	<.001	<.001	3	9
URINARY_TRACT	Phosphatidylserine exposure on apoptotic cell surface →	-0.275	-1.335	<.001	<.001	3	9
BLOOD_Myeloma	Peptidyl-amino acid modification →	+0.034	+1.078	.002	.007	3	9
STOMACH	Protein sumoylation →	+0.078	+1.241	<.001	<.001	3	8
BONE	Regulation of syncytium formation by plasma membrane fusion →	+0.096	+1.149	<.001	<.001	3	8
STOMACH	piRNA-mediated gene silencing by mRNA destabilization →	+0.246	+1.269	.003	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,080 associations by consensus.

Engulfment of apoptotic cell by XKR6 expression — BONE

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