XKR6

Across TCGA cell cohorts, XKR6 mutation is significantly associated with the RNA expression of many other genes, with 691 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XKR6-associated genes across cancer lineages are FAM160A1, ABCD3, and STIL. Each is linked with XKR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both XKR6-to-partner and partner-to-XKR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM160A1 grouped by XKR6-low versus XKR6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR6→partner) and Y-score (partner→XKR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	FAM160A1 →	+0.728	+3.125	.004	.008	3	2
LARGE_INTESTINE	ABCD3 →	+0.586	+3.252	.004	.002	3	2
LARGE_INTESTINE	STIL →	+0.557	+3.386	.006	.001	3	2
LARGE_INTESTINE	RAP1GDS1 →	+0.550	+3.628	.002	<.001	3	2
LARGE_INTESTINE	DCK →	+0.600	+3.628	.001	<.001	3	2
LARGE_INTESTINE	NAE1 →	+0.557	+3.169	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 691 associations by consensus.

FAM160A1 by XKR6 expression — LARGE_INTESTINE

Explore this box plot interactively →