XKR5

Across TCGA patient cohorts, XKR5 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XKR5-associated genes across cancer lineages are Caspase-7-cleavedD198, ERK2, and JNK_pT183_Y185. Each is linked with XKR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both XKR5-to-partner and partner-to-XKR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by XKR5-low versus XKR5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR5→partner) and Y-score (partner→XKR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.896	+3.827	<.001	<.001	3	2
UCEC	ERK2 →	+0.160	+2.502	.034	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.151	-2.999	.022	.035	3	1
UCEC	JNK2 →	+0.153	+2.834	.049	.034	3	1
UCEC	MEK1 →	+0.358	+2.584	.012	.010	3	1
UCEC	MSH2 →	-0.224	-2.433	.013	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Caspase-7-cleavedD198 by XKR5 expression — UCEC

Explore this box plot interactively →