Across TCGA patient cohorts, XKR4 protein abundance is significantly associated with the RNA expression of many other genes, with 1,436 significant associations in total. GBM shows the largest number of these associations.

The most reproducible XKR4-associated genes across cancer lineages are GRK3, SLC16A8, and RASL10A. Each is linked with XKR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both XKR4-to-partner and partner-to-XKR4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR4→partner) and Y-score (partner→XKR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GRK3 →	+0.471	+0.446	.002	.003	3	1
GBM	SLC16A8 →	+0.593	+0.592	<.001	.001	3	1
GBM	RASL10A →	+1.107	+0.820	<.001	<.001	3	1
GBM	NEFH →	+1.084	+0.627	<.001	<.001	3	1
GBM	RASD2 →	+0.499	+0.618	.002	<.001	3	1
GBM	PDGFB →	+0.448	+0.577	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,436 associations by consensus.

Exploration

XKR4 survival (RNA) · tumor vs normal (RNA) · all XKR4 data types