Across TCGA patient cohorts, XKR4 mutation is significantly associated with the RNA expression of many other genes, with 6,791 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XKR4-associated genes across cancer lineages are PTMAP9, PCK2, and MRPS22. Each is linked with XKR4 in more than 5 cancer types. Because this analysis shows association rather than direction, both XKR4-to-partner and partner-to-XKR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR4→partner) and Y-score (partner→XKR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PTMAP9 →	+0.688	+3.584	<.001	.002	3	6
CESC	PCK2 →	+0.414	+2.130	.009	.009	3	5
STAD	MRPS22 →	+0.439	+3.668	.001	.001	3	5
UCEC	UTP11 →	+0.332	+1.592	<.001	<.001	3	5
UCEC	TXNRD1 →	+0.550	+1.219	<.001	.001	3	5
UCEC	PSMA6 →	+0.328	+1.815	.005	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,791 associations by consensus.

Exploration

XKR4 survival (RNA) · tumor vs normal (RNA) · all XKR4 data types