Across TCGA patient cohorts, XKR4 mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XKR4-associated genes across cancer lineages are PCNA, 4E-BP1, and PDCD4. Each is linked with XKR4 in more than 3 cancer types. Because this analysis shows association rather than direction, both XKR4-to-partner and partner-to-XKR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR4→partner) and Y-score (partner→XKR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.269	+2.078	<.001	<.001	3	4
UCEC	4E-BP1 →	+0.377	+1.544	<.001	<.001	3	4
UCEC	PDCD4 →	-0.590	-1.887	<.001	<.001	3	4
UCEC	ATM →	-0.465	-2.446	<.001	<.001	3	4
SKCM	14-3-3_epsilon →	+0.069	+1.222	.020	.025	3	4
LUSC	GAPDH →	+0.861	+1.935	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

Exploration

XKR4 survival (RNA) · tumor vs normal (RNA) · all XKR4 data types