Across TCGA cell cohorts, XKR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,136 significant associations in total. BONE shows the largest number of these associations.

The most reproducible XKR4-associated GO terms across cancer lineages are Negative regulation of protein localization to plasma membrane, Negative regulation of protein localization to cell periphery, and Positive regulation of striated muscle cell apoptotic process. Each is linked with XKR4 in more than 3 cancer types. Because this analysis shows association rather than direction, both XKR4-to-partner and partner-to-XKR4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR4→partner) and Y-score (partner→XKR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of protein localization to plasma membrane →	-0.145	-1.026	.001	.001	3	4
BONE	Negative regulation of protein localization to cell periphery →	-0.108	-1.314	.004	.001	3	4
CNS	Positive regulation of striated muscle cell apoptotic process →	+0.096	+0.266	.006	.008	3	3
CNS	Positive regulation of cardiac muscle cell apoptotic process →	+0.096	+0.266	.006	.008	3	3
SKIN	Cell migration involved in vasculogenesis →	-0.130	-0.163	.001	.007	3	3
SKIN	Xenobiotic transport →	-0.079	-0.088	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,136 associations by consensus.

Exploration

XKR4 survival (RNA) · tumor vs normal (RNA) · all XKR4 data types