Across TCGA cell cohorts, XKR4 mutation is significantly associated with the RNA expression of many other genes, with 216 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XKR4-associated genes across cancer lineages are DBX2, WFDC10A, and HTR1A. Each is linked with XKR4 in more than 1 cancer types. Because this analysis shows association rather than direction, both XKR4-to-partner and partner-to-XKR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR4→partner) and Y-score (partner→XKR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DBX2 →	+0.006	+5.000	<.001	.006	3	1
LUNG_SCLC	WFDC10A →	+1.099	+4.817	<.001	.001	3	1
BLOOD_Lymphoma	HTR1A →	+0.022	+5.643	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.605	+3.160	.001	.006	3	1
LARGE_INTESTINE	ZC3H14 →	+0.596	+3.502	<.001	.001	3	1
LARGE_INTESTINE	METTL4 →	+0.683	+3.067	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 216 associations by consensus.

Exploration

XKR4 survival (RNA) · tumor vs normal (RNA) · all XKR4 data types