Across TCGA cell cohorts, XKR4 mutation is significantly associated with the mutation status of many other genes, with 5,647 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XKR4-associated genes across cancer lineages are ARHGAP21, FLG2, and COL16A1. Each is linked with XKR4 in more than 5 cancer types. Because this analysis shows association rather than direction, both XKR4-to-partner and partner-to-XKR4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XKR4→partner) and Y-score (partner→XKR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ARHGAP21 →	+3.357	+3.532	.005	.005	1	6
CNS	FLG2 →	+3.277	+3.954	.004	.004	1	6
BLOOD_Lymphoma	COL16A1 →	+4.584	+4.584	.007	.007	1	5
BREAST	PCDHB12 →	+5.297	+5.297	.004	.004	1	5
SKIN	ARHGEF28 →	+3.357	+3.532	.005	.005	1	5
BLOOD_Leukemia	LRRK1 →	+2.584	+3.640	.003	.003	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,647 associations by consensus.

Exploration

XKR4 survival (RNA) · tumor vs normal (RNA) · all XKR4 data types