XK

Across TCGA pan-cancer cohorts, XK Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated XK data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher XK Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated XK expression acts as an unfavorable survival marker.

KIRC, LUSC, and CESC are the cancer types where XK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.122	0.811	<.001	36	view →
LUSC	DFS	Median	All	0.154	0.712	.002	30	view →
CESC	OS	Median	All	0.276	0.800	<.001	18	view →
ESCA	OS	Median	II,III,IV	0.248	0.686	.019	9	view →
SKCM	OS	Median	III,IV	0.230	0.721	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

XK–KIRC (OS)

Open the KIRC breakdown →