XK

Across TCGA patient cohorts, XK mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XK-associated genes across cancer lineages are PAI-1, HSP70, and TAZ. Each is linked with XK in more than 1 cancer types. Because this analysis shows association rather than direction, both XK-to-partner and partner-to-XK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by XK-low versus XK-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XK→partner) and Y-score (partner→XK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PAI-1 →	+0.883	+3.178	.002	.010	3	2
COAD	HSP70 →	+0.562	+2.820	.044	.035	3	1
COAD	TAZ →	+0.353	+3.195	<.001	.010	3	1
UCEC	14-3-3_beta →	-0.123	-2.973	<.001	<.001	3	1
UCEC	EGFR_pY1068 →	-0.249	-1.678	.003	.021	3	1
UCEC	A-Raf_pS299 →	-0.122	-1.765	.002	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PAI-1 by XK expression — COAD

Explore this box plot interactively →