XK

Across TCGA cell cohorts, XK mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible XK-associated genes across cancer lineages are TCF21, NPSR1, and KRTAP12-3. Each is linked with XK in more than 1 cancer types. Because this analysis shows association rather than direction, both XK-to-partner and partner-to-XK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF21 grouped by XK-low versus XK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XK→partner) and Y-score (partner→XK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TCF21 →	+0.011	+4.705	<.001	.003	3	1
BLOOD_Leukemia	NPSR1 →	+0.025	+4.152	<.001	.009	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.084	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR1D5 →	+0.029	+4.969	<.001	.003	3	1
LARGE_INTESTINE	CLPSL1 →	+0.158	+4.054	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TCF21 by XK expression — BLOOD_Leukemia

Explore this box plot interactively →