XIRP2

Across TCGA patient cohorts, XIRP2 mutation is significantly associated with the total protein of many other genes, with 111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XIRP2-associated genes across cancer lineages are Cyclin-B1, ASNS, and PCNA. Each is linked with XIRP2 in more than 6 cancer types. Because this analysis shows association rather than direction, both XIRP2-to-partner and partner-to-XIRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by XIRP2-low versus XIRP2-high in KIRC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XIRP2→partner) and Y-score (partner→XIRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRC	Cyclin-B1 →	+0.648	+3.006	.001	.020	3	7
COAD	ASNS →	+0.410	+1.387	<.001	.004	3	7
STAD	PCNA →	+0.316	+2.415	<.001	.002	3	6
STAD	TFRC →	+0.540	+2.700	.002	.004	3	6
STAD	4E-BP1 →	+0.380	+2.392	<.001	<.001	3	6
COAD	Rad50 →	-0.177	-1.637	.006	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 111 associations by consensus.

Cyclin-B1 by XIRP2 expression — KIRC

Explore this box plot interactively →