XIRP2

Across TCGA cell cohorts, XIRP2 mutation is significantly associated with the RNA expression of many other genes, with 1,308 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible XIRP2-associated genes across cancer lineages are PYROXD1, HIPK4, and INTS8. Each is linked with XIRP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both XIRP2-to-partner and partner-to-XIRP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PYROXD1 grouped by XIRP2-low versus XIRP2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XIRP2→partner) and Y-score (partner→XIRP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PYROXD1 →	+0.459	+1.822	.008	<.001	3	4
LUNG_NSCLC_LUAD	HIPK4 →	+0.079	+1.596	.004	.008	3	4
LUNG_NSCLC_LUAD	INTS8 →	+0.399	+2.036	.008	<.001	3	4
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	4
SKIN	NKX2-4 →	+0.398	+2.234	.002	<.001	3	3
LUNG_NSCLC_LUAD	TXNDC12 →	+0.420	+1.844	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,308 associations by consensus.

PYROXD1 by XIRP2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →