XIAPP1

Across TCGA patient cohorts, XIAPP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,049 significant associations in total. STAD shows the largest number of these associations.

The most reproducible XIAPP1-associated GO terms across cancer lineages are Golgi ribbon formation, Establishment of mitotic sister chromatid cohesion, and Ribosome-associated ubiquitin-dependent protein catabolic process. Each is linked with XIAPP1 in more than 19 cancer types. Because this analysis shows association rather than direction, both XIAPP1-to-partner and partner-to-XIAPP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi ribbon formation grouped by XIAPP1-low versus XIAPP1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XIAPP1→partner) and Y-score (partner→XIAPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Golgi ribbon formation →	+0.055	+0.164	<.001	<.001	3	20
ESCA	Establishment of mitotic sister chromatid cohesion →	+0.058	+0.161	<.001	<.001	2	20
PCPG	Ribosome-associated ubiquitin-dependent protein catabolic process →	+0.055	+0.061	<.001	<.001	3	19
ESCA	COPII-coated vesicle cargo loading →	+0.092	+0.211	<.001	<.001	3	19
STAD	Negative regulation of telomere capping →	+0.036	+0.138	<.001	<.001	3	18
UCS	Negative regulation of protein sumoylation →	+0.064	+0.078	.004	.002	2	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,049 associations by consensus.

Golgi ribbon formation by XIAPP1 expression — ESCA

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