XIAP-AS1

Across TCGA pan-cancer cohorts, XIAP-AS1 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated XIAP-AS1 data layer.

The strongest signal is observed in thyroid carcinoma (THCA), where higher XIAP-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated XIAP-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

THCA, KIRC, and HNSC are the cancer types where XIAP-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THCA	DFS	Tertile	III,IV	0.444	0.854	<.001	49	view →
KIRC	DFS	Tertile	All	0.748	0.820	.008	28	view →
HNSC	OS	Quartile	II,III,IV	0.594	0.342	.004	25	view →
BLCA	OS	Median	II,III,IV	0.688	0.550	.008	19	view →
READ	OS	Median	IV	0.490	0.878	.004	18	view →
MESO	DFS	Tertile	IV	0.144	0.448	.008	15	view →
SKCM	OS	Tertile	IV	0.133	0.621	.019	12	view →
OV	DFS	Quartile	IV	0.469	0.247	.037	8	view →
STAD	OS	Quartile	IV	0.662	0.231	.019	3	view →
BRCA	OS	Tertile	IV	0.887	0.611	.025	3	view →
LGG	DFS	Median	All	0.895	0.816	.036	3	view →
KIRP	DFS	Median	All	0.486	0.668	.030	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

XIAP-AS1–THCA (DFS)

Open the THCA breakdown →