XDH

Across TCGA pan-cancer cohorts, XDH Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated XDH data layer compared with 25 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher XDH Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated XDH expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

CESC, UCEC, and OV are the cancer types where XDH Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	II,III,IV	0.178	0.790	<.001	42	view →
UCEC	DFS	Median	All	0.962	0.824	.008	30	view →
OV	DFS	Median	All	0.168	0.541	.005	18	view →
COAD	OS	Median	All	0.564	0.876	.008	9	view →
LIHC	OS	Median	All	0.393	0.780	<.001	9	view →
LGG	OS	Median	All	0.238	0.799	<.001	7	view →
GBM	DFS	Median	All	0.043	0.243	.003	6	view →
SCLC	OS	Median	II,III,IV	0.203	0.830	.011	3	view →
SKCM	OS	Median	II,III,IV	0.914	0.826	.037	3	view →
STAD	OS	Median	III,IV	0.960	0.613	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

XDH–CESC (DFS)

Open the CESC breakdown →