XDH

Across TCGA patient cohorts, XDH protein abundance is significantly associated with the RNA expression of many other genes, with 10,039 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible XDH-associated genes across cancer lineages are LIPK, ITGA3, and PDZK1IP1. Each is linked with XDH in more than 5 cancer types. Because this analysis shows association rather than direction, both XDH-to-partner and partner-to-XDH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XDH versus LIPK in HNSC, with a Pearson correlation of 0.26.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XDH→partner) and Y-score (partner→XDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LIPK →	+1.072	+0.577	.002	.001	2	6
LSCC	ITGA3 →	+1.066	+1.058	<.001	<.001	3	5
BRCA	PDZK1IP1 →	+1.768	+0.927	.001	<.001	3	5
BRCA	TGM5 →	+0.617	+0.492	<.001	.003	3	4
UCEC	GALNT14 →	+1.309	+0.606	<.001	.008	3	4
LUAD	DENND2B →	+0.720	+1.090	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,039 associations by consensus.

XDH vs LIPK — HNSC

Explore this scatter interactively →