XDH

Across TCGA patient cohorts, XDH mutation is significantly associated with the RNA expression of many other genes, with 5,383 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XDH-associated genes across cancer lineages are CKS1B, UQCRH, and TRUB2. Each is linked with XDH in more than 3 cancer types. Because this analysis shows association rather than direction, both XDH-to-partner and partner-to-XDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CKS1B grouped by XDH-low versus XDH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XDH→partner) and Y-score (partner→XDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CKS1B →	+0.473	+2.523	.008	<.001	3	4
UCEC	UQCRH →	+0.698	+1.480	<.001	<.001	3	4
UCEC	TRUB2 →	+0.355	+2.315	<.001	<.001	3	4
UCEC	COQ2 →	+0.289	+1.157	.008	.008	3	4
UCEC	TIPIN →	+0.526	+2.230	<.001	<.001	3	4
UCEC	AHSA1 →	+0.372	+1.491	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,383 associations by consensus.

CKS1B by XDH expression — UCEC

Explore this box plot interactively →