XDH

Across TCGA cell cohorts, XDH RNA expression is significantly associated with the go_rna of many other GO terms, with 4,618 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible XDH-associated GO terms across cancer lineages are Guanine metabolic process, Cellular response to indole-3-methanol, and Regulation of protein deubiquitination. Each is linked with XDH in more than 11 cancer types. Because this analysis shows association rather than direction, both XDH-to-partner and partner-to-XDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Guanine metabolic process grouped by XDH-low versus XDH-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XDH→partner) and Y-score (partner→XDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Guanine metabolic process →	-0.252	-2.252	<.001	<.001	3	12
PANCREAS	Cellular response to indole-3-methanol →	+0.204	+1.780	<.001	<.001	3	11
STOMACH	Regulation of protein deubiquitination →	+0.202	+1.500	<.001	<.001	3	11
BREAST	Positive regulation of iron ion transport →	+1.466	+1.534	<.001	<.001	3	10
BREAST	Positive regulation of iron ion transmembrane transport →	+1.466	+1.534	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of defense response to virus by host →	+0.118	+1.245	<.001	.004	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,618 associations by consensus.

Guanine metabolic process by XDH expression — URINARY_TRACT

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