XDH

Across TCGA cell cohorts, XDH mutation is significantly associated with the RNA expression of many other genes, with 822 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible XDH-associated genes across cancer lineages are LCE6A, LCE2B, and C12orf40. Each is linked with XDH in more than 2 cancer types. Because this analysis shows association rather than direction, both XDH-to-partner and partner-to-XDH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE6A grouped by XDH-low versus XDH-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XDH→partner) and Y-score (partner→XDH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	LCE6A →	+0.060	+4.906	<.001	.006	3	2
SOFT_TISSUE	LCE2B →	+0.024	+4.392	<.001	.004	3	2
OVARY	C12orf40 →	+0.010	+4.444	<.001	.001	3	2
LARGE_INTESTINE	METTL4 →	+0.521	+1.949	.001	.002	3	2
LARGE_INTESTINE	ACBD5 →	+0.641	+1.949	.003	.002	3	2
LARGE_INTESTINE	GPR63 →	+0.777	+1.807	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 822 associations by consensus.

LCE6A by XDH expression — OESOPHAGUS

Explore this box plot interactively →