XCR1

Across TCGA pan-cancer cohorts, XCR1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated XCR1 data layer compared with 25 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher XCR1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated XCR1 expression acts as an unfavorable survival marker.

HNSC, OV, and PRAD are the cancer types where XCR1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.441	0.770	.024	9	view →
OV	DFS	Median	All	0.132	0.541	.001	6	view →
PRAD	DFS	Median	All	0.047	0.935	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	OS	Median	All	0.680	0.872	.009	6	view →
LUSC	DFS	Median	II,III,IV	0.135	0.663	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

XCR1–HNSC (OS)

Open the HNSC breakdown →