XCR1

Across TCGA patient cohorts, XCR1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible XCR1-associated genes across cancer lineages are 4E-BP1, eEF2, and EGFR_pY1068. Each is linked with XCR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both XCR1-to-partner and partner-to-XCR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by XCR1-low versus XCR1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XCR1→partner) and Y-score (partner→XCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.263	+3.029	.031	.018	3	2
UCEC	eEF2 →	+0.427	+2.000	.008	.032	3	1
UCEC	EGFR_pY1068 →	-0.254	-3.807	.024	<.001	3	1
UCEC	eIF4E →	+0.259	+2.700	.006	.006	3	1
UCEC	JNK2 →	+0.254	+3.009	.004	.019	3	1
UCEC	MEK1 →	+0.421	+3.459	.010	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

4E-BP1 by XCR1 expression — UCEC

Explore this box plot interactively →