XCR1

Across TCGA cell cohorts, XCR1 RNA expression is significantly associated with the go_rna of many other GO terms, with 370 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible XCR1-associated GO terms across cancer lineages are Vascular associated smooth muscle cell differentiation, Positive regulation of macroautophagy, and Positive regulation of hair follicle development. Each is linked with XCR1 in more than 2 cancer types. Because this analysis shows association rather than direction, both XCR1-to-partner and partner-to-XCR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Vascular associated smooth muscle cell differentiation grouped by XCR1-low versus XCR1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (XCR1→partner) and Y-score (partner→XCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Vascular associated smooth muscle cell differentiation →	+0.175	+0.012	<.001	.004	3	3
LARGE_INTESTINE	Positive regulation of macroautophagy →	+0.053	+0.144	<.001	.004	3	3
PANCREAS	Positive regulation of hair follicle development →	+0.151	+0.013	<.001	.003	3	3
PANCREAS	Post-translational protein targeting to endoplasmic reticulum membrane →	+0.061	+0.010	.005	.005	3	3
PANCREAS	Phospholipase C-activating serotonin receptor signaling pathway →	-0.118	-0.010	.008	.005	3	3
BLOOD_Leukemia	Left/right pattern formation →	-0.029	-0.014	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 370 associations by consensus.

Vascular associated smooth muscle cell differentiation by XCR1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →