XCR1

Across TCGA cell cohorts, XCR1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible XCR1-associated genes across cancer lineages are OR7G2, CCL19, and ASCL4. Each is linked with XCR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both XCR1-to-partner and partner-to-XCR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR7G2 grouped by XCR1-low versus XCR1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (XCR1→partner) and Y-score (partner→XCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR7G2 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	CCL19 →	+0.139	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	ASCL4 →	+0.013	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR2L5 →	+0.012	+4.887	.001	.009	3	1
LUNG_NSCLC_LUAD	OR13C3 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	MLN →	+0.118	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OR7G2 by XCR1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →