XBP1P1

Across TCGA patient cohorts, XBP1P1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,174 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible XBP1P1-associated proteins across cancer lineages are PHF2_S458, PHF2_S905, and RBM14_T206. Each is linked with XBP1P1 in more than 3 cancer types. Because this analysis shows association rather than direction, both XBP1P1-to-partner and partner-to-XBP1P1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, XBP1P1 versus PHF2_S458 in LSCC, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (XBP1P1→partner) and Y-score (partner→XBP1P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PHF2_S458 →	+0.432	+0.308	<.001	.004	3	3
CCRCC	PHF2_S905 →	+0.740	+0.575	<.001	<.001	3	3
CCRCC	RBM14_T206 →	+0.196	+0.292	<.001	.002	3	3
GBM	CDK13_S525 →	+0.347	+0.477	.001	<.001	3	3
CCRCC	AKAP12_S1226 →	-0.449	-0.475	.003	<.001	3	3
OV	RSF1_S1310 →	-1.028	-0.707	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,174 associations by consensus.

XBP1P1 vs PHF2_S458 — LSCC

Explore this scatter interactively →