XBP1

Across TCGA pan-cancer cohorts, XBP1 Mutation is linked to patient survival in 2 of 34 cancer types, making it the most broadly survival-associated XBP1 data layer compared with 1 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher XBP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated XBP1 expression acts as an unfavorable survival marker.

MESO and COAD are the cancer types where XBP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.144	0.557	.029	15	view →
COAD	DFS	Median	III,IV	0.028	0.649	<.001	15	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

XBP1–MESO (OS)

Open the MESO breakdown →